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(2002) Prevalence and risk fac-tors of silent brain infarcts in the population-based RotterdamScan Study. After the initial 1- to 2-week course of IV therapy, switch tooral therapy can be considered.

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Theadministration of exogenous surfactants in infantswith RDS is effective to prevent the combinedrisk of death and BPD, but generally not the riskof BPD alone (Soll 2000 , 2010).

However, simple aminer-gic deficiency as an explanatory hypothesis has fallen bythe wayside and been largely discredited, in the contextof enormous evidence that depression is signifi cantlymore complicated than a simple “deficiency” state in anymonoaminergic system, singly or even collectively (for asummary of the history, see Healy, 1997).

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